Prostatakarzinom und Ernährung

Stanley A Brosman | 12. Juni 2012

Entzündung und Prostatakrebs

Klein et al. von der “Cleveland Clinic“ haben eine Hypothese herausgearbeitet, die eine Verbindung zwischen Entzündung und Prostatakarzinom sieht (15). Eine prostatische Entzündung ist mit oxidativem Stress verbunden, der die Produktion von reaktiven Sauerstoff- (ROS) und Stickstoffspezies (RNS) stimuliert. Diese binden an die DNS und verursachen Mutationen. Oxidativer Stress endo- oder exogener Herkunft ist mit DNS-Schäden assoziiert, die das Alterns hervorrufen und an der Karzinogenese beteiligt sein können. Mehrfach ungesättigte Fettsäuren induzieren die Entstehung von ROS, woraus wiederum Fettradikale mit DNS-Schädigungspotenzial resultieren. Samenflüssigkeit kann wegen des gelegentlichen Vorkommens von Leukozyten und einem erheblichen Anteil an mehrfach ungesättigten Fettsäuren ebenfalls oxidativ sein.

Unterschiedliche Reparaturmechanismen zur Verhinderung oder Korrektur oxidativer Schäden sind bekannt. Antioxidative Enzyme wie die Phospholipase A-2 entfernt veränderte Fettsäuren, ROS and RNS und beugt so Mutationen vor. Dieses eine Positivbeispiel ernährungsassoziierter Antioxidantien dient als Erkenntnis, dass die Nahrungsaufnahme ROS- und RNS- assoziierter Nahrungsmittel limitiert oder vermieden werden sollte.

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Autoren und Interessenskonflikte

Autor

Stanley A Brosman, MD Clinical Professor, Department of Urology, University of California, Los Angeles, David Geffen School of Medicine
Keine Interessenskonflikte

Koautoren

Mark A Moyad MD, MPH, ND Phil F Jenkins Director of Complementary and Alternative Medicine, Department of Urology, University of Michigan Medical Center
Interessenkonflikt: Abbott Labs (Honorare Sprechen und Lehren); Farr Labs Consulting (Consulting); Guthy Renker Consulting (Consulting); Guthy Renker Royalty (Andere)

Chefredakteur

Edward David Kim, MD, FACS Professor of Surgery, Division of Urology, University of Tennessee Graduate School of Medicine; Consulting Staff, University of Tennessee Medical Center
Interessenkonflikt: Lilly Consulting (Advisor); Astellas Consulting (Sprechen und Lehren); Watson Consulting (Sprechen und Lehren); Allergan Consulting (Sprechen und Lehren)

Weitere Mitarbeiter

Gamal Mostafa Ghoniem, MD, FACS Professor of Urology, Chief, Division of Female Urology, Pelvic Reconstructive Surgery, and Voiding Dysfunction, Department of Urology, University of California, Irvine, School of Medicine
Interessenkonflikt: Astellas Honoraria (Sprechen und Lehren); Coloplasty Consulting (Board membership); Uroplasty Consulting (Consulting)

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Interessenkonflikt: Mitarbeiter von Medscape

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